Journal of Japan Society for Blood Purification in Critical Care
Online ISSN : 2434-219X
Print ISSN : 2185-1085
Experimental investigation of the effect of conditions for performing pre-dilution continuous hemofiltration on blood return temperature using the TR-2020 blood purification system
Takumi AokiKazuki FujishiroItsuro ShimamineYasuyuki WatanabeKoichi KashiwaHitoshi KuboRyota InokuchiKent Doi
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JOURNAL FREE ACCESS

2025 Volume 16 Issue 2 Pages 105-109

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Abstract

During continuous hemofiltration (CHF), an increase in replacement fluid flow rate may cause insufficiently warmed replacement fluid to enter the blood circuit, potentially contributing to a decrease in body temperature. In addition, since the pre-dilution method allows a higher replacement fluid flow rate than the post-dilution method, the temperature drop in the blood circuit may be more pronounced. No previous studies have investigated the association between the warming temperature of the replacement fluid and the return blood temperature under the pre-dilution method. Therefore, we aimed to evaluate the effects of the warming temperature of the replacement fluid within the blood circuit. The results showed that when the replacement fluid flow rate was increased without heating the replacement fluid, the temperature in the circuit decreased markedly, and when the replacement fluid temperature was increased to 37℃ or 40℃, the temperature in the circuit also tended to increase, but did not exceed that of the de-hemorrhaging site. These findings suggest that while warming of the replacement fluid is necessary to mitigate temperature decreases within the blood circuit during CHF, warming of replacement fluid alone may not be sufficient to completely prevent temperature reductions.

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© 2025, Japan Society for Blood Purification in Critical Care
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