2025 Volume 16 Issue 2 Pages 95-99
【Background】Acute blood purification therapy for critically ill pediatric patients remains challenging, and limited data are available in Japan.【Objective】This study aimed to clarify the current status of acute blood purification therapy in pediatric intensive care patients.【Methods】This retrospective study included patients aged＜15 years who required continuous hemodiafiltration or continuous hemodialysis in the Pediatric Intensive Care Unit (PICU) of Hyogo prefectural Kobe Children’s Hospital between May 2016 and March 2024.【Results】We included 48 patients, with a median age of 4 years 1 month and median body weight of 12.6kg. The treatment modes included continuous hemodialysis in 31 patients, continuous hemodiafiltration in 17. In total, 29 cases (60.4%) survived until discharge. Survival rates were low in patients with hematologic/oncological diseases (28.6%), congenital heart disease, post-cardiac arrest (30%), and those requiring extracorporeal membrane oxygenation (ECMO) (33.3%). Complications included venous thrombosis (one case) and intracranial hemorrhage (one case). In renal replacement therapy, the time from PICU admission to continuous renal replacement therapy initiation, fluid overload, and ECMO use were more frequent in the non-survivor group.【Conclusion】Prospective multicenter case studies are necessary.
