Temperature change in the circuit for continuous blood purification therapy

Abstract

During continuous blood purification (CBP) therapy, the temperature of the blood fluctuates with changes in certain conditions between blood transmission and removal. In this context, we investigated the change in temperature of each circuit part of the CBP apparatus and the calorific loss with changes in the blood circulation rate (Qb), dialysate flow rate (Qd), replacement flow rate (Qs), and in the temperature of the dialysate and replacement fluids(warmer temperature setting of 37℃), under conditions where blood temperature was simulated as 37℃ and room temperature as 27℃. Among the circuit parts, heat loss was significantly high in the hemofilter, whereas no heat loss was observed in the air trap chamber. The heat loss increased in direct proportion to increased blood circulation under specific conditions. When the fluids and diasylate used in the CBP process are not heated, hyperthermia increases at 30-50cal/min with every increase of 0.5L/h in Qd or Qs. In contrast, when the fluids and dialysate are appropriately heated, hyperthermia decreases with approximately 30cal/min of heat loss with every increase of 0.5 L/h in Qd or Qs.