2013 Volume 4 Issue 1 Pages 38-42
The aim of this retrospective study was to compare the lifetimes of two hemofilters---polysulfone and cellulose triacetate---to determine when sudden hypercoagulation occurred in continuous renal replacement therapy (CRRT). One group was set for no changes of the polysulfone hemofilter (PS) (number (n)=59）and the other was to change the cellulose triacetate hemofilter (CTA) (n=33) when the polysulfone hemofilter was coagulated. There were no differences in the basic characteristics of the patients who used PS and CTA filters. Also no differences were noted in hemofilter life-time and total doses of nafamostat before hemofilters were exchanged. However, the substitution flow rate (531±243mL/hr in PS group and 391±234mL/hr in CTA group) were different (P＜0.05). After exchange, 61.1％ of CTA filters were coagulation free during 24 hrs. In contrast, only 25.0％ of PS filters were coagulation free. Hemofilter life times were 18.6±14.5 hr and 27.6±13.1 hr in the PS and CTA groups, respectively. (P＜0.05). Judging from these results, the exchange of PS to CTA filter would be effective in case of coagulation.
