The effectiveness of the combination the Long-Term Direct hemoperfusion with Polymyxin B immobilized fiber (PMX-DHP) therapy and Continuous hemodiafiltation (CHDF) for severe sepsis / septic shock

Abstract

Recently, the effectiveness of Long-Term PMX-DHP treatment is reported. We introduced the combination therapy (long term combination method) PMX-DHP and PMMA-CHDF using PMMA membrane at our hospital intensive care unit during from October, 2012. We performed a retrospective study of the clinical usability on the long term combination method. The targets are the 44 cases that had a diagnosis of a septic shock, and treated the long term combination method and/or the PMX-DHP (2 hours), with enforced the PMMA-CHDF (conventional method) at our hospital intensive care unit during the period from October, 2010 to March, 2014. The outcome measures, we had used systolic pressure, catecholamine index, lactic acid level in blood, PaO₂/FiO₂ ratio (P/F ratio), for the numbers of platelet transition, we divided into two groups; the long term combination method group and the conventional method group. In the long term combination method group, there is a tendency to diachronic drop of Catecholamine Index, and it showed the significant improvements during from the initiating the therapy to after 6 hours, but no significant difference was observed between the two groups. Further examination will be necessary in future to prove the effectiveness of Long-Term combination method.