Comparison of frequent low-efficiency and short hemodialysis with frequent low-efficiency and short hemofiltration in hemodialysis patients with acute brain injury

Abstract

【Purpose】This study aimed to determine the effects of frequent low-efficiency and short hemodialysis(FLESHD)in comparison with frequent low-efficiency and short hemofiltration (FLESHF) in hemodialysis (HD) patients with acute brain injury (ABI).【Methods】We randomly divided 14 HD patients with ABI into the FLESHD (n=7) or FLESHF (n=7) group. Conditions for the first to third sessions were as follows. FLESHD: intravenous administration of glycerol 400 mL/session, blood flow rate (QB) 100 mL/min, dialysate flow rate 300 mL/min, and duration 2 h. FLESHF: intravenous administration of glycerol 400 mL/session, QB 150 mL/min, substitution flow rate 10 L/session, and duration 4 h. Conditions were gradually changed from the fourth session onward.【Results】There were no significant differences in survival rate, consciousness level, or adverse effects during hospitalization between the groups. Additionally, no significant differences were seen in the levels of osmolality, blood pressure before and after treatment, or in the level of HCO₃^－ before treatment. However, the level of HCO₃^－ after FLESHD was significantly lower than that after FLESHF, and extracorporeal circulation time was significantly shorter in the FLESHD group.【Conclusions】FLESHD with glycerol under these conditions may be a better therapeutic option for managing patients with ABI.