Retrospective study of transmembrane pressures and lifespan of UT-2100S and CH-1.8W hemofilters during high-flow volume-continuous hemodiafiltration

Abstract

【Objective】 In this study, we examined whether high-flow volume-continuous hemodiafiltration (HFV-CHDF) can be performed safely with CH-1.8W or UT-2100S hemofilters for 24h in our intensive care unit. We compared the transmembrane pressures (TMP) at onset of CHDF and the time course-associated changes in TMP with CH-1.8W and UT-2100S hemofilters. 【Materials and methods】 The subjects included patients who underwent HFV-CHDF between April and May 2014. HFV-CHDF was performed as follows: QB, 100 mL/min; QD, 900 mL/h; and QF, 900 mL/h. The time course-associated changes in TMP during CHDF and rate of discontinuation of CHDF due to coagulation in the hemofilter were retrospectively investigated. HFV-CHDF was performed with a CH-1.8W hemofilter (CH-1.8W group) or UT-2100S hemofilter (UT-2100S group). 【Results】 The rate of discontinuation of CHDF due to coagulation was comparable in the CH-1.8W and UT-2100S groups. The mean TMP at the onset of CHDF was markedly higher in the CH-1.8W group compared with the UT-2100S group. In addition, the time course-associated changes in TMP were higher in the CH-1.8W group compared with the UT-2100S group. Both CH-1.8W and UT-2100S hemofilters comparably performed HFV-CHDF. 【Conclusion】 TMP was higher in the CH-1.8W group compared with the UT-2100S group because of differences in the membrane structures and properties. However, the lifespan of CH- 1.8W and UT-2100S hemofilters were comparable, and both hemofilters safely performed HFV-CHDF for 24h.