Plasma exchange for the standardization of acute blood purification

Abstract

Plasma exchange (PE) involves the removal of separated plasma and subsequent infusion of the same amount of plasma fraction or fresh frozen plasma. PE is used to eliminate pathogenic substances. However, some adverse effects have been reported, including hypernatremia, metabolic alkalosis, citrate poisoning, and abrupt changes in the colloid osmotic pressure. To minimize such adverse effects, PE is combined with hemodiafiltration or albumin dialysis therapy in medical institutions. In the interactive session in 2014, there remains much room for discussion about the clinical indication, type and duration of PE, choice of replacement solution, etc. To perform PE in a standardized manner, such project should be discussed in the interactive session of the conference.