Comparative study of life-time and various values of PMMA membrane with different surface areas under CHDF in progress

Abstract

Using a 1.0m² and 1.8m² PMMA membrane hemofilter, a comparative study was made on life-time and each type of pressure value. A crossover was made using CH-1.0SX, CH-1.8W. Setting blood flow at 100mL/min, dialysate at 570mL/hr and filtration flow at 100mL/hr, ACT was controlled to be 200～350s on the retransfusion side. Pressure values of inlet-venous difference pressure, transmembrane pressure (TMP) were compared, and timing of circuit switching set at inlet pressure 350mmHg and greater, TMP 250mmHg and greater, and past 48 hours. Using Wilcoxon signed-rank sum test for statistical examination, p-value＜0.05 was considered as showing a significant difference. No case of circuit coagulation during CHDF was noticed, nor significant difference in operating time. Significant difference was seen in pressure values of both inlet-venous difference pressure and TMP. Different membrane surface areas didn’t show any difference in life-time, but both inlet pressure and TMP showed low values with CH-1.8W, indicating expectations for prolonged life-time, so further studies should be made.