2016 Volume 7 Issue 1 Pages 31-37
The filter life and amount of total protein adsorption were examined for CH-1.8W (inside diameter of the hollow fiber: 240μm, membrane surface area: 1.8m2, material: polymethylmethacrylate) and BK-2.1P (inside diameter of the hollow fiber: 200μm, membrane surface area: 2.1m2, material：polymethylmethacrylate). Long-term in vitro continuous hemofiltration (CHF) experiments with porcine whole blood were performed using a blood flow rate of 100mL/min, and a replacement fluid flow rate and filtration fluid rate of 10mL/min. The filter life was evaluated by the times at which the transmembrane pressure (TMP) and pressure drop reached 200mmHg or their derivatives reached 15mmHg/hr. Both the TMP and pressure drop were stable for several hours from the start of the experiments, but increased rapidly after the certain period of time, which was almost the same for both CH-1.8W and BK-2.1P. The amount of total protein adsorption was significantly higher with BK-2.1P than with CH-1.8W.
