Factors related to hemolysis, internal circuit pressure, and hemolysis in Continuous Renal Replacement Therapy

Abstract

We investigated the factors related to hemolysis, internal circuit pressure, and hemolysis in Continuous Renal Replacement Therapy (CRRT). We targeted 14 patients who underwent CRRT at AKI from April 2015 to December 2015 at the institution. The index of hemolysis was determined as plasma free hemoglobin value and measured 24h after the start of CRRT. On the basis of the blood removal pressure, arterial chamber pressure, venous chamber pressure, and transmembrane pressure difference the patients were categorized into the following two groups：the hemolysis group (＞30mg/dL; 5 cases) and the non-hemolytic group (＜30mg/dL; 9 cases). We also examined factors related to hemolysis. A significant difference was observed between the two groups (blood removal pressure, arterial chamber pressure, venous chamber pressure) (p＜0.05). Additionally, arterial chamber pressure [odds ratio: 1.222 （95% CI: 0.984-1.517), p=0.043)] was a factor related to hemolysis when a binomial logistic regression analysis was performed. Hemolysis was related to internal circuit pressure, and arterial chamber pressure was thought to be related to hemolysis. Additionally, monitoring of circuit pressure in CRRT was considered effective for preventing hemolysis.