Abstract
Kahlbaum assumed that catatonia would be developed from organic disease. Endogenous psychosis is one of the causes of catatonia, however it seems that not a few patients with catatonic symptoms can be developed by the effects of physical disease. We investigated 3 patients who were difficult to diagnose. Notably, the patient in case 1 could not be diagnosed from her state when we considered the possibility of 3 causes: catatonia, neuroleptic malig-nant syndrome, and encephalitis. The patient was treated with intensive therapy and achieved a good recovery, then, was finally diagnosed with non-herpetic limbic encephalitis. Herein, we discuss the relationship between catato-nia and encephalitis including non-herpetic limbic encephalitis, anti-NMDAR encephalitis and smilar disease.