Pathogenesis and biomarkers of psychiatric symptoms with systemic lupus erythematosus

Abstract

Systemic lupus erythematosus (SLE) is a chronic, multisystemic, autoimmune disease that may involve the central, peripheral, and autonomic nervous systems and can present with a wide variety of neurological and psychiatric manifestations. However, there are few biomarkers which always reflect the severity of the psychiatric symptoms with SLE. In this review, recent advances in the pathogenesis and biomarkers of neuropsychiatric systemic lupus erythematosus (NPSLE) were outlined.