Abstract
Increasing evidence from cross-sectional and longitudinal magnetic resonance imaging (MRI) studies in first-episode schizophrenia and individuals at risk for developing psychosis (at risk mental state : ARMS) suggests that 1. ARMS subjects who subsequently develop psychosis have baseline brain changes, which could be at least partly predictive of later transition, and that 2. patients with schizophrenia and other psychoses have progressive brain morphologic changes during the transition period as well as initial periods after the onset of florid psychosis. In this article we review recent neuroimaging findings in early psychosis and also refer to remaining issues to be addressed before transferring these neurobioligical research findings to the clinical setting.
