Abstract
It came to be able to use three kinds of acetylcholinesterase inhibitors for the treatment of Alzheimer’s disease. In the metaanalysis study there is no significant difference in improvement of cognitive function between these three acetylcholinesterase inhibitors. However, the pharmacological action, indication, medicinal form, frequency of administration and the period to reaching the maintenance dose are different in these three medicine. Sufficient assessment of patients condition need to selection and changing in these medicine for the treatment of Alzheimer’s disease.