2012 Volume 23 Issue 2 Pages 115-120
The biological markers, such as pentosidine, vitamin B6 and genotype of the glyoxalase I (GLO1) are useful for classifying heterogeneous psychotic syndromes in to homogeneous each types, early diagnosis and state of disease stage in schizophrenic patients with enhanced carbonyl stress. Moreover, pyridoxamine, one of the three forms of vitamin B6, which functions as a carbonyl scavenger is expected to become the therapeutic value of schizophrenia, in addition to be effective in the personalized medicine. In this review, our translational research on carbonyl stress was introduced, and the creation of medical treatment, preventive medicine for carbonyl stress and the prospective view towards omics- based medicine was described.
