Abstract
Induced pluripotent stem cells (iPSCs) are derived through reprogramming somatic cells into a pluripotent embryonic stem cell (ESC)-like state. Generated iPSCs are capable to differentiate into various cell types including neuronal cells. The disease modeling using patient iPSC-derived neuronal cells would elucidate disease pathogenesis and contribute to drug discovery for neurodegenerative diseases. We report our recent progress toward understanding of neurodegenerative diseases using iPSC technology.
