Abstract
This symposium addressed the pathological role of mitochondrial dysfunction and related new therapeutic perspectives in neuropsychiatric disorders. The translocator protein (18 kD) shows neuroprotective and antiinflammatory effects, and thus may be valuable for the treatment of neurologic diseases. The molecular mechanism underlying the PINK1-dependent mitochondrial translocation and activation of Parkin is an initial step of mitophagy. Prevention of activation of Parkin may be useful for treatment and diagnostic marker in the early stage of Parkinson’s disease. Neonatal MK- 801 treatment induced dysregulation in the p70S6K - S6/eIF4B pathway and protein translation in the frontal cortex of the developing rat brain, suggesting an important role of protein translation machinery in animal model of schizophrenia. Supplementation with omega-6/omrga- 3 ratio of 4/1 remarkably improved ASD symptoms and upregulation of signaling.
