Japanese Journal of Biological Psychiatry
Online ISSN : 2186-6465
Print ISSN : 2186-6619
The pathophysiological role and therapeutic potential of brain peptides in psychiatric disorders : traslocator protein and its related MK-801, and antioxidants
Kunio Yui
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2014 Volume 25 Issue 2 Pages 85-89

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Abstract
This symposium addressed the pathological role of mitochondrial dysfunction and related new therapeutic perspectives in neuropsychiatric disorders. The translocator protein (18 kD) shows neuroprotective and antiinflammatory effects, and thus may be valuable for the treatment of neurologic diseases. The molecular mechanism underlying the PINK1-dependent mitochondrial translocation and activation of Parkin is an initial step of mitophagy. Prevention of activation of Parkin may be useful for treatment and diagnostic marker in the early stage of Parkinson’s disease. Neonatal MK- 801 treatment induced dysregulation in the p70S6K - S6/eIF4B pathway and protein translation in the frontal cortex of the developing rat brain, suggesting an important role of protein translation machinery in animal model of schizophrenia. Supplementation with omega-6/omrga- 3 ratio of 4/1 remarkably improved ASD symptoms and upregulation of signaling.
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© 2014 Japanese Society of Biological Psychiatry
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