Abstract
Blood (plasma or/and serum) levels were lower in patients with major depressive disorder (MDD) than those with healthy controls. In addition, a negative correlation was observed between the HAMD scores and blood BDNF levels. In the present study, we predicted the relapse of major depressive episode based on plasma BDNF levels, and we found plasma BDNF levels in relapse group decreased at least 6 months after the follow up point (baseline), however, those in remission group did not. The decrease in blood BDNF is an objective biological marker for relapse of majar depressive episode.
