Abstract
The concepts of carbonyl stress (CS), oxidative stress (OS) and advanced glycation end products (AGEs) are the greatest feature of this research. Treatment-resistant schizophrenia (TRS) has consistent features by attempting to consolidate basic and clinical data on schizophrenia with CS presenting with depletion of vitamin B6 and accumulation of pentosidine, an AGE. The features and innovativeness of this research are in its reconsideration of pathologies that can be expanded from the “individual” to the “general” level. The research outcomes will be applied to drug development by establishing a new field of research in molecular psychiatry focused on CS, OS and AGEs. Data obtained from metabolic studies, genome research, cell models, animal models, and post-mortem brain research will be consolidated to elucidate genetic and environmental factors for psychological disorders, and the aggregated basic and clinical data will be consolidated and arranged in order to conduct research that makes appropriate use of “omics data” .
