Abstract
Diagnosis of mental illness has been made by a physician examining the symptoms, however, objective diagnosis method has not yet been established yet. It is necessary to examine a sufficient period of time to obtain information on symptoms and course necessary for diagnosis. Because there are difficulties in obtaining the required information in limited consultation hours in clinical practice, there is a need to develop objective and scientific diagnosis. In this paper, history of mental illness diagnosis, DSM (Diagnostic and Statistical Manual of Mental Disorders) , and RDoC (Research Domain Criteria) are explained. And the way of clinical application by the multicenter study of COCORO (Cognitive Genetics Collaborative Research Organization) is outlined concerning one of the leading objective auxiliary diagnostic method candidate, cognitive dysfunction in patients with schizophrenia. Finally, diagnostic criteria proposed for a new schizophrenia are introduced including the outlook for the future.