Abstract
The clinical state of depression includes occurrence, response, acute phase, remission, relapse, and recurrence. It reminds us that their dynamic way is based on a neuroplastic change. In addition, ‘resilience’ is the suitable concept to study the prevention of depression and the condition of mild depression. In this review, I summarize the neuroplastic change, breakdown and modification by the nurturing environment of hypothalamic-pituitary-adrenocortical axis.
