Abstract
Schizophrenia mainly occurs in puberty and adolescence, positive symptoms such as hallucinations and delusions, negative symptoms such as desire to motivation and emotion obsessive, cognitive impairment, etc. are observed, and many are related to chronic and recurrent course with a decline in social function. Schizophrenia is highly integrated in families, genome research focusing on its genetic factors was conducted. 108 risk loci were successfully identified by GWAS with large scale samples, and drug discovery based on these genes is expected. Advances in neuroimaging and neurophysiological research have also been remarkable, especially eye movement can be expected from objective auxiliary diagnostic methods. Furthermore, Measurement of cognitive decline could be an objective diagnostic method, as a measurement method is established for cognitive decline and the treatment method also changes depending on the presence or absence of cognitive decline. Although diagnostic methods are focused on intermediate phenotypes in this way, molecules / genes are necessary for development of therapeutic methods, and a translational approach is further expected.
