Abstract
Accumulating evidence suggests a key role of the N-methyl-D-aspartate (NMDA) receptor in the pathophysiology of post-traumatic stress disorder (PTSD) . Recent studies suggest that the NMDA receptor antagonist ifenprodil tartrate may be a potential therapeutic drug for PTSD. The purpose of this study is to confirm whether ifenprodil tartrate is effective in the treatment of adolescents (13-18 years old) PTSD patients. If ifenprodil tartrate is effective in these patients, this study contributes to the development of novel therapeutic drugs for PTSD.
This study is an interventional, randomized, parallel assignment, double blinded clinical trial. The primary outcome measure is Impact of Event Scale-Revised Japanese Version: IES-R-J and the secondary outcome measure are Trauma Symptom Checklist for Children Japanese Version: TSCC-J, Children’s Depression Rating Scale-Revised: CDRS-R, Depression Self-Rating Scale for Children Japanese Version: DSRS-C-J and CGI-scores. [Time Frame: Changes from baseline in these scores at 4-weeks]
