Human blood research of mood disorders focusing on microglia hypothesis

Abstract

Microglia, immune cells in the brain, has recently been highlighted to understand the pathophysiology of mood disorders especially depression. Herein, we introduced our novel translational research system of mood disorders using [1] directly induced microglia‐like (iMG) cells, which can be produced from human peripheral monocytes within two weeks with two cytokines ; GM‐CSF and IL‐34, and [2] human plasma/serum analysis such as metabolomics.