Abstract
Neurodevelopmental hypothesis of psychiatric disorders, by definition, requires developmental understanding of psychiatric disorders. Human cerebral cortex, for example, has many areas that differ in their cytoarchitecture and function, and they have distinct pathophysiological significance in patients with psychiatric disorders. We know very little about areal differences in brain development, however. Deep understandings of how the whole brains are formed by diverse cells provide great opportunity to study possible local and global vulnerability of human brains. Investigating the causal relationship between this vulnerability and psychiatric disorders would lead us to the understanding of the pathogenesis. In summary, the advancement of the study on the pathogenesis of psychiatric disorders would require deep understanding of normal brain development.
