Abstract
In Japan, Japan Brain Bank Net (JBBN) is currently operating by eight major brain banks, and postmortem brain research is expected to be conducted more actively in the future. On the other hand, studies using peripheral tissues that can be collected with relatively low invasiveness are also important for the researches of psychiatric disorders. However, in the studies using peripheral tissues, the significant of findings and the relationship between peripheral and central tissues are always questioned. In this article, we introduce our researches using peripheral blood samples derived from patients with psychiatric diseases. Furthermore, we introduce and discuss comparative studies of peripheral blood and postmortem brain studies. Since the findings obtained in both tissues are not always consistent, both approaches will be necessary to reveal the pathophysiology of psychiatric disorders and develop biomarkers.
