Phase‐amplitude coupling in the auditory cortex in schizophrenia : an EEG study

Abstract

Cross‐frequency interactions may coordinate neural circuits operating at different frequencies. Here we examined phase‐amplitude coupling (PAC) in the electroencephalograms of individuals with schizophrenia (SZ) and healthy control subjects (HCs) . We computed PAC during the baseline period of 40‐Hz auditory steady‐state stimulation and rest. We reanalyzed data from 18 subjects with SZ and 18 HCs. Overall, coupling of β and γ amplitude was higher during the auditory steady‐state response, while α/β PAC was higher during rest. θ/α PAC was higher in subjects with SZ than in HCs. θ/γ PAC was lateralized to the left hemisphere in HCs but was not lateralized in subjects with SZ. There are no potential conflicts of interest to disclose.