The neuroinflammatory hypothesis of suicidal behavior

Abstract

The etiology of suicidal behavior is poorly understood while the pathology of various neuropsychiatric disorders has recently been reported to be closely associated with neuroinflammation. There may be subtypes or clinical stages in various neuropsychiatric disorders, on which the inflammatory processes have a profound influence. These processes may account for the underlying mechanism of clinical manifestations such as treatment‐ resistance, severe symptoms, and suicidal behavior observed in neuropsychiatric disorders. The relationship between suicidal behavior and neuroinflammation may shed a new light on the development of new diagnostic and therapeutic strategy for suicidal behavior.