Abstract
As underlying pathological hypotheses of both depression and Alzheimer’s disease (AD) , neuroinflammation hypothesis and BDNF hypothesis are recently drawing attention. In addition, lifestyle‐related diseases such as diabetes and obesity are also involved in the pathogenesis of both depression and AD, indicating that it is very important to review daily lifestyles such as diet, exercise, and sleep to prevent and delay the onset of depression and AD. Moreover, activation of microglia is also involved in the pathophysiology of depression and AD. Recent reports suggest that microglial senescence as a new therapeutic target to protect and potentiate the function of residual microglia, including phagocytic activity of amyloid‐β (Aβ) .
