Abstract
The authors identified DMRs (differentially methylated regions) in neurons and non-neurons by DNA methylation analysis using MBD2B in frontal lobe samples of patients with bipolar disorder. In both cell types, the promoter region showed global hypomethylation, and gene-specific hypermethylation was observed in neurons. The background of gene-specific hypermethylation was considered to be the increased expression of DNMT3B. We also showed that mood stabilizers showed methylation changes in the opposite direction to the postmortem brain, and that DMRs were significantly accumulated in the GWAS region of bipolar disorder.
