Abstract
Circadian rhythms are the fundamental phenomena in almost all of the living organisms. In mammals, these rhythms are associated with not only physiological systems and behaviors, but also mental health. Several disorders such as cancer, metabolic syndrome and sleep disorders are known to be triggered by circadian dysfunctions. Understanding the circadian responses and functions of these disorders probably contribute to development for therapeutic strategy. Recently, several works have indicated the relationship between chronotypes and mood disorders that morning person of chronotype is tended to stress resilience. Therefore, recent attempt to analyse the chronobiological aspects of mood disorders and stress responses is getting more attention.
In this review, we introduce the recent advances between mammalian circadian rhythms and mood disorders such as stress, depression and bipolar disorders including our data that the mice with a clock ASPS variant are resilient to chronic stress.
