2023 Volume 34 Issue 3 Pages 117-119
Repetitive head trauma can induce chronic traumatic encephalopathy (CTE) . CTE is defined as tauopathy because of neuropathologic findings indicative of tau deposition, such as neurofibrillary tangles. Single moderate to severe traumatic brain injury can also produce CTE-like psychiatric and neurological symptoms and neuropathological changes in the chronic phase. Tau imaging in the chronic phase of single moderate to severe single traumatic brain injury shows focal accumulation of tau tracer at the depths of cerebral sulci in some cases. Neuroinflammation can be one of the factors involved in tau pathology in traumatic brain injury. In selecting reference tissues for tau imaging, it is important to consider that the cerebellum is an area where tau can accumulate in CTE.
