Abstract
Diseases associated with functional abnormalities of the central dopamine neurons include Parkinson’s disease, restless legs syndrome, Tourette syndrome, attention‐deficit hyperactivity disorder (ADHD) , dependence on stimulants and other substances, and psychosis due to using psychoactive substances. Accordingly, there are many other diseases besides schizophrenia. Here, we review previous animal experiments using symptom models of Parkinson’s disease, ADHD, substance dependence, and schizophrenia, and reconsider the dopamine hypothesis of schizophrenia. An overview of these dopamine‐related disorders reveals that the symptoms of each disorder are different and cannot be defined solely by dopamine activity level, which may prove the low disease specificity between dopamine neurons dysfunction and each dopamine‐related disorder.
