Abstract
While recent advances in MRI technology have enabled high‐precision brain imaging, challenges remain in data quality consistency across different MRI systems and research reproducibility. Brain/MINDS Beyond addresses these issues through a large‐scale MRI study across 18 Japanese institutions, encompassing over 7,000 participants (healthy controls and neuropsychiatric patients) . The program introduced the Harmonized Protocol (HARP) for standardization across different MRI manufacturers and models. Using traveling subjects to assess inter‐scanner variations, we achieved high‐quality multimodal MRI data within a 30‐minute protocol, including structural (0.8mm isotropic) , functional (2.4mm isotropic, 10min) , and diffusion MRI (1.7mm isotropic) . The study established standardized preprocessing methods based on the HCP Pipeline and developed various analytical approaches for investigating brain functional and microstructural architecture. The resulting high‐precision database and analytical framework provide a robust foundation for understanding brain organization and neuropsychiatric pathophysiology, with promising applications in clinical diagnosis and prognosis prediction.
