Abstract
Leucine specific transaminase was induced very rapidly in rat liver by hydrocortisone, but this induction was inhibited completely by simultaneous injection of growth hormone. Hypophysectomy did not affect the magnitude of the induction but greatly extended the duration of the induction period. Repeated injections of corticoid also prolonged the induction period. The enzyme was induced in adrenalectomized rats 24 hours after administration of a high protein diet. This induction was affected significantly by neither administration of growth hormone nor hypophysectomy. The inductions by hydrocortisone and a high protein diet were additive, but hydrocortisone caused no induction in rats fed on a non protein diet. Insulin alone induced the enzyme but did not increase the induction by a high protein diet. Glucagon showed no effect. Induction of leucine specific transaminase under these treatments are discussed.
