An Important Role of Prostacyclin in Porcine Thyroid Cells In Culture: Augmentation of Prostacyclin by TSH in Culture, Increase of Prostacyclin after Acute TSH-stimulation in TSH Treated Cells and Stimulation of c AMP Synthesis and Iodine Metabolism by Prostacyclin; Prostacyclin Plays an Important Role in the Presence of TSH

Abstract

Cultured porcine thyroid cells produce PGE₂, PGF_2α , TXA₂ and PGI₂. PGE₂ and PGI₂ stimulate c AMP synthesis and iodine metabolism. When cultured in the presence of TSH, the cells produce PGI₂ and when cultured in the absence of TSH, the cells produce PGE₂, PGF_2α , and TXA₂. TSH acutely stimulates PGE₂ and PGI₂ syntheses. When cultured in the presence of TSH, TSH acutely stimulates PGI₂ synthesis and when cultured in the absence of TSH, TSH acutely stimulates PGE₂ synthesis. In the presence of TSH, PGI₂ plays more important role than other PGs.