Abstract
The effects of two synthetic polyethyleneglycol flufenamates on plasmin and urokinase were investigated using fluorogenic peptide substrates. These flufenamates increased the plasmin activity about 1.5 times, and the urokinase activity about twice under optimum conditions. Moreover, they increased plasmin formation from plasminogen by urokinase 3-fold.
They did not influence the antiplasmin activity of human plasma or the activation of plasminogen in plasma by urokinase or streptokinase.
These findings show that the two flufenamates increase the activity of plasmin and urokinase, and the plasmin forming activity of urokinase in a purified system.
