Abstract
p-Guanidinobenzoate derivatives were prepared, and their inhibitory effects on trypsin, plasmin, pancreatic kallikrein, plasma kallikrein, thrombin, Clr and Clesterase were examined.Among the various inhibitors tested, 6-amidino-2-naphthyl-4-guanidino benzoate·dihydrochrolide, 6-(β-amidinoethenyl) phenyl-4-guanidinobenzoate·dimethanesul.fonate and 6-amidino-2-benzoylphenyl-4-guanidin- benzoate·dimethanesulfonate were the moste ffective inhibitors of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein and thrombin, and they strongly inhibited the esterolytic activities of Clr and Clesterase, and then strongly inhibited complemernt-mediated hemolysis.
