Interference of Cefoxitin on Urinary 17-OHCS Assay
1982 Volume 11 Issue 2 Pages 144-145
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1982 Volume 11 Issue 2 Pages 144-145
Interference of Cefoxitin (antibiotics) on urinary 17-OHCS assay is described. This drug and its metabolites show a reactivity with color reagent of 17-OHCS in which phenylhydrazine is dissolved.
In contrast with Cephalexin which shows reactivity with both color reagent and blank reagent of 17-OHCS, Cefoxitin shows reactivity only with color reagent so that results obtained show positive error, for example, 1 g of dose gives assay values of 10 to 15 mg/day as 17-OHCS excretion.
Furthermore, color produced by the reagent has a yellow same as Porter-Silber chromogen, so that the effect of this drug could not be recognized by an analyst.
From these results, it is preferable to quit an administration of this drug before the test
