Clinical Application of Purine Metabolic Enzyme Activities in Sera

Abstract

Adenosine deaminase, purine nucleoside phosphorylase and guanase activities in sera of patients with various diseases were determined by the new colorimetric methods.
It was observed that the serum guanase activity increased specifically in liver disorders and correlated with serum transaminase activity. Although the serum adenosine deaminase activity also increased in liver diseases, the clinical value of adenosine deaminase may be different from that of guanase.
It was found that the serum purine nucleoside phosphorylase activity, which increased in patients with malignant lymphoma and systemic lupus erythematosus, correlated with the amount of sensitized lymphocyte.