Determination of Polyamines in Uremic Erythrocytes by High-Performance Liquid Chromatography

Abstract

The levels of putrescine, cadaverine, spermidine and spermine in uremic erythrocytes were determined by high-performance liquid chromatography-Spermidine and cadaverine were significantly (p<0.05) higher in 10 patients with chronic renal failure than in 8 normal subjects.Putrescine and spermine values were only slightly elevated.The erythrocyte polyamines were also measured in the patients before and after hemodialysis.The spermidine content was lowered but those of the other polyamlnes Were not.