Serum Manganese-Superoxide Dismutase Level in Patients with Liver Diseases

Abstract

Changes in serum manganese superoxide dismutase level in the course of liver diseases were monitored in order to elucidate more precisely the relationship between diseases andserum superoxide dismutase level. Manganese-superoxide dismutase activity had good correlations with some other enzyme activities in patients with acute hepatitis, liver cancer, liver cirrhosis and alcoholic cirrhosis, but it had no correlation with such enzyme activities in case of subacute hepatitis and chronic hepatitis. Studies onthe clinical course in liver diseases demostrated that the change of manganese-superoxide dismutase was later than that of other enzymes. The amounts of manganese-superoxide dismutase may be in- creased not only due to release from the injured cells, but also due to induction in order to exclude the superoxide anion radical which is produced in inflammation.