New Synthetic Inhibitors of Chymotrypsin, Trypsin, Thrombin, Plasmin, Urokinase, Tissue Plasminogen Activator, Factor Xa, Tissue Kallikrein, and Plasma Kallikrein

Abstract

p-Amidinophenylester derivatives were prepared and their inhibitory effects on chymotrypsin, trypsin, thrombin, plasmin, tissue plasminogen activator (TPA), urokinase, factor Xa, tissue kallikrein, plasma kallikrein, and elastase were examined. Among the various synthetic inhibitors tested, aromatic carboxylates of p-amidinophenol were the most effective inhibitors of chymotrypsin, trypsin, thrombin, plasmin, TPA, urokinase, factor Xa, tissue kallikrein, and plasma kallikrein.