1988 Volume 16 Issue 4 Pages 202-210
We evaluated an automated clinical analyzer, the Du Pont aca® SX with two commercial control sera (Du Pont Liquid Multi-analyte Calibrator and Ortho Tri-level TDM Control). Analytical recovery was 80-113% throughout the assays of 16 drug items [Du Pont Liquid Multi-analyte Calibrator (6 items), 80-113%; Ortho Tri-level TDM Control (16 items), 88-110%]. Within-run reproducibilities for the assays of 14 items in both commercial control sera were less than 10% of the coefficient of variation (CV), whereas the CV's for amikacin and gentamicin were 14.8% and 25%, respectively. Between-day reproducibilities for the assays of 14 items were small, and were not significant in comparison with those of the within-run assays. The concentrations of none of the items in either control serum changed during storage at 4 or -220°C for 30 days.
We concluded that the automated clinical analyzer Du Pont aca® SX is useful for routine assay of serum drugconcentrations based on the results obtained with the Du Pont Liquid Multi-analyte Calibrator and Ortho Tri-level TDM Control. Moreover, the Du Pont aca® SX was found to be a useful instrument for emergency assays of serum drug concentrations because is based on a rapid, simple, and accurate method.
