1992 Volume 21 Issue 2 Pages 149-151
Dibucaine- and fluoride-inhibition on serum cholinesterase (ChE: EC 3.1.1.8) have been given with several substrates. When using DMBT (2, 3-dimethoxy thiobenzoyl choline) as substrates, inhibition by dibucaine seemed to be less effective. TIPA (tetraisopropylpyrophosphoramide) which is known as one of the most potent inhibitors does inhibit cholinesterase activities severely and yet presents, some residual activities under DMBT conditions. These conditions suggests that DMBT may serve as another unknown esterase substrate.