Proposed Standard for Certified Enzyme Reference Material (ERM)

Abstract

The certified enzyme reference material (ERM) for the standardization of catalytic concentration measurement of enzymes was applied to the recommended methods proposed by the Japan Society of Clinical Chemistry (JSCC) for the measurement of the catalytic concentration of six serum enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK), alkaline phosphatase (ALP), lactate dehydrogenase (LD) and gamma-glutamyltransferase (γ -GT). This ERM should mainly be used for the establishment of transferability in the enzyme measurement system, may also be applied to the development and assessment of a measurement methods and assignment of values of enzyme concentration for enzyme calibrators and material for quality assurance systems.