Japanese Journal of Clinical Chemistry
Online ISSN : 2187-4077
Print ISSN : 0370-5633
Determination of Drugs Using Natural/Synthetic Receptors
Toshifumi Takeuchi
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1997 Volume 26 Issue 1 Pages 1-6

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Abstract

In-vitro tests using isolated receptors for the binding of ligands, that is receptor assays, are powerful tools for determining of physiological/ pharmacological activities of biologically active substances. In this article, receptor assays for benzodiazepine drugs are described, including radioreceptor assays and non-isotopic receptor assays. Competitive binding assays using synthetic receptors are also described as a newly developed technique, in which the synthetic receptors are prepared by a molecular imprinting technique. Typical data obtained by these three receptor assays are shown and the characteristics and usefulness of each assay are reviewed.

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