Clinical Siginificance of Serum Carboxypeptidase A Activity (II)

Relationship between serum Carboxypeptidase activity and pancreatic exocrine function test

Abstract

The relationships between the serum Carboxypeptidase A activity (CPase) and the results of exocrine function tests of the pancreas were studied. The following results were obtained.
(1) Concerning the relationships between the CPase and three factors in pancreozymin-secretin (PS) test, significant correlation was observed between CPase and total amylase output (r=0.571, p<0.005) or maximum bicarbonate concentration (r=0.415, p<0.05), but no significant correlation was observed between CPase and volume flow per kilogram.
(2) While 80% of patients with normal level of CPase was also within normal ranges in PS test, about 70% of patients with abnormal low level of CPase activity, we found any degree of dysfunction in PS test.
(3) No significant correlation was found between CPase and the results of ¹³¹l-triolein test.
(4) Low levels of CPase were observed in patients whose pancreatic scanning showed abnormality. It seems to be significantly correlated between the CPase activity in serum and the results of the exocrine function tests of pancreas.