Abstract
Since the elevated level of guanidinosuccinic acid was demonstrated in sera of uremic patient by Bonas et al.(1963), so many studies have been focused on analyses of gua-nidino compounds as uremic toxins. In this monograph, more than 50 of naturally occurring guanidino compounds were classified, and analytical methods for guanidino compounds were reviewed compactly as follows:
I. Classification of naturally occurring guanidino compounds
1. Guanidine and its derivatives
·guanidine ·methylguanidine ·dimethylguanidine ·hydroxyguanidine
2. ω-Guanidino acids and its derivatives
·guanidinoacetic acid (glycocyamine) ·β-guanidinopropionic acid ·γ-guanidinobutyric acid ·γ-guanidinobutyramide ·δ-guanidinovaleric acid ·creatine ·asterubine ·argininic acid (α-hydroxy-δ-guanidinovaleric acid) ·α-keto--guanidinovaleric acid
3. Acidic guanidino acid
·guanidinosuccinic acid ·α-guanidinoglutaric acid
4. Arginine and its derivatives
·arginine ·α-N-acetylarginine ·agmatine ·methylagmatine ·δ-N-hydroxyarginine ·acetylagmatine ·γ-hydroxyarginine ·α-N-acetyl-r-hydroxyarginine ·NG, NG-dimethylarginine ·NG, N'G-dimethylarginine ·octopine ·arginosuccinic acid ·canavaninosuccinic acid ·suberylarginine ·homoarginine
5. Guan'dinoethane derivatives
·taurocyamine (guanidinoethylsulfonic acid) ·hypotaurocyamine (guanidinoethylsulfinic acid) ·guanidinoethylmethylphosphate (opheline) ·guanidinoethylserylphosphate (lombricine) ·guanidinoethyl-(α-N, N-dimethyl) serylphosphate (thalassemine) ·guanidinoethylaspartylserylphosphate (aspartyllombricine) ·asterubine
6. Diguanidino compounds
·arcaine (diamidinoputrescine) ·audouine (diamidinocadaverine) ·hirudonine (diamidinospermidine) ·vitiatin
7. Phosphagenes
·argininephosphate ·creatinephosphate ·glycocyaminephosphate ·taurocyaminephosphate ·hypotaurocyaminephosphate ·ophelinephosphate ·lombricinephosphate ·thalasseminephosphate
8. Others
·galegine ·phascoline ·phascolosomine ·canavanine ·streptidine ·creatinine
II. Analytical methods for guanidino compounds
1. paper chromatography and thin layer chromotography
2. liquid column chromatography
3. gas chromatography-mass spectrometry
